October WKW Frontiers in Neuroscience Lecture Series: Ebrahim Haroon, M.D.

Ebrahim Haroon, M.D. - October 4, 2022 

"Inflammation, Glutamate, and Gila in Depression - Revisited"
William K. Warren, Jr.  Frontiers in Neuroscience Lecture 

12:00 pm - 1:00 pm     Program in the LPCH auditorium
11:00am - 11:45am      Lunch will be served beforehand in the LPCH banquet room

Dr. Haroon has worked hard in producing high quality, high impact original work on the impact of inflammation on the brain.  He is the leading investigator on the effects of inflammation on brain glutamate and its downstream consequences on local and regional neural integrity and ultimately the integrity of neural circuitry and their regulation of behavior. The relevance of these effects of inflammation to aging is an additional unique and notable aspect of his work.  Dr. Haroon has published high impact papers and has been funded by NIH including two grants that are being completed.  Dr. Haroon is also a chartered member of APDA - a standing study section and has participated in international activities in Asia and Europe giving lectures on his work throughout the world.  He is a member of American College of Neuropsychopharmacology (ACNP) and serves on the Editorial Board of Brain, Behavior, and Immunity and Psychoneuroendocrinology. Dr. Haroon continues to teach residents in the Emory Resident Psychopharmacology Training Clinic and serves as the Associate Director of the Emory Behavioral Immunology Program.  Dr. Haroon is well respected for his scientific work and is well respected by his peers, being invited to present in and Chair symposiums at prestigious meetings including ACNP.  He and his work represent the depth of the Emory Psychiatry's research "bench". In this presentation, Dr. Haroon will revisit and update the original hypothesis presented in in 2017 Review on Neuropsychopharmacology. He will present data linking subacute and chronic inflammation with glial pathology and glutamate dysregulation in depression. He has written several chapters in major textbooks including the forthcoming edition of Sadock’s Comprehensive Textbook of Psychiatry.

Learning objectives: 

1. Appreciate the role in inflammatory activation in depression.
2. Examine mechanisms by which peripheral inflammation accesses the brain system.
3. Target inflammatory mechanisms to treat depression.