THE KHALSA LABORATORY
Sahib S. Khalsa, M.D., Ph.D.Director of Clinical Operations, Laureate Institute for Brain Research
Associate Professor, University of Tulsa, Oxley College of Health Sciences Director, LIBR Float Clinic and Research Center Volunteer Faculty Member, Department of Psychiatry, University of Oklahoma Curriculum Vitae Google Scholar Profile Email: skhalsa@laureateinstitute.org | Phone: 918-502-5743
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Research Program Highlights
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Main Question
How does the connection between brain and body determine physical and mental health? Approach Use pharmacological and non-pharmacological perturbations to influence body physiology, and evaluate how this changes bodily feelings, emotional experience, and neural activity in humans. Currently studying the heart-brain connection and gut-brain connection in individuals with eating and anxiety disorders. |
Future Directions
To determine whether systematically retraining the brain body connection reduces psychopathology and could yield new therapeutics for psychiatric disorders. |
Scientific Biography
Dr. Khalsa received a bachelor’s degree in psychology with honors from SUNY Stony Brook in 2002. He graduated from the Medical Scientist Training Program at the University of Iowa, receiving M.D. and Ph.D. (neuroscience) degrees in 2009. He completed his residency training in Psychiatry at UCLA in 2013, serving as the program Chief Resident and Chief Resident in the UCLA Anxiety Disorders Clinic. He subsequently joined the department as an Assistant Professor in Residence in the Division of Adult Psychiatry at UCLA. In 2015, Dr. Khalsa joined the Laureate Institute for Brain Research in Tulsa, Oklahoma, as the Director of Clinical Studies, and as an Assistant Professor (tenure track) on the Faculty of Community Medicine at the University of Tulsa. In 2020, Dr. Khalsa became the Director of Clinical Operations, and an Associate Professor (with tenure) on the Faculty of Community Medicine at the University of Tulsa.
Dr. Khalsa’s research investigates the role of interoception in mental and physical health, with a focus on understanding how changes in internal physiological states influence body perception and the functioning of the human nervous system. His studies utilize a variety of approaches to probe cardiovascular, respiratory, and gastrointestinal interoception including via pharmacological and non-pharmacological techniques, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and computational modeling. Central aims of this work are to discover modifiable neuroscience-based treatment targets for psychiatric disorders, to develop tests to identify these treatment targets in individual patients, and to design neuroscience-based therapies capable of ameliorating the symptoms and signs of mental illness.
Dr. Khalsa’s clinical expertise focuses on the assessment and treatment of anxiety disorders. Dr. Khalsa previously served as Associate Director of the UCLA Anxiety Disorders Clinic, supervising resident physicians in the treatment of anxiety disorders, and was an attending psychiatrist in the UCLA OCD Intensive Outpatient Program. As founding Director of the Healthy Hearts Behavioral Medicine Program, an interdisciplinary endeavor started with the UCLA Cardiac Arrhythmia Center, he specializes in treating anxiety and mood disorders in individuals with cardiac arrhythmias. Current activities include conducting case conferences with the Laureate Psychiatric Hospital and Clinic, running psychoeducation groups with inpatients from the Laureate Eating Disorders Program, supervising diagnostic assessments of participants enrolling in clinical trials, providing safety monitoring for ongoing randomized clinical trials, and co-facilitating psychiatry resident journal clubs.
Dr. Khalsa’s research investigates the role of interoception in mental and physical health, with a focus on understanding how changes in internal physiological states influence body perception and the functioning of the human nervous system. His studies utilize a variety of approaches to probe cardiovascular, respiratory, and gastrointestinal interoception including via pharmacological and non-pharmacological techniques, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and computational modeling. Central aims of this work are to discover modifiable neuroscience-based treatment targets for psychiatric disorders, to develop tests to identify these treatment targets in individual patients, and to design neuroscience-based therapies capable of ameliorating the symptoms and signs of mental illness.
Dr. Khalsa’s clinical expertise focuses on the assessment and treatment of anxiety disorders. Dr. Khalsa previously served as Associate Director of the UCLA Anxiety Disorders Clinic, supervising resident physicians in the treatment of anxiety disorders, and was an attending psychiatrist in the UCLA OCD Intensive Outpatient Program. As founding Director of the Healthy Hearts Behavioral Medicine Program, an interdisciplinary endeavor started with the UCLA Cardiac Arrhythmia Center, he specializes in treating anxiety and mood disorders in individuals with cardiac arrhythmias. Current activities include conducting case conferences with the Laureate Psychiatric Hospital and Clinic, running psychoeducation groups with inpatients from the Laureate Eating Disorders Program, supervising diagnostic assessments of participants enrolling in clinical trials, providing safety monitoring for ongoing randomized clinical trials, and co-facilitating psychiatry resident journal clubs.
Lab Members
Emily Adamic
Graduate Student |
Jaimee Bruce, R.N.
Clinical Research Coordinator |
Emily Choquette, Ph.D.
Post-Doctoral Research Associate |
McKenna Garland
Graduate Student |
Alexa Morton
Research Specialist |
Adam Teed, Ph.D.
Post-Doctoral Research Associate |
Charles Verdonk, M.D., Ph.D.
Post-Doctoral Research Affiliate French Armed Forces Biomedical Research Institute |
Raminta Wilson, M.D., M.P.H.
Psychiatric Research Coordinator, LIBR FLoat Clinic and Research Center |
Research Volunteers
Michael Flux Caruso
Gabriel Morrison
Jonas L. Steinhäuser
Gabriel Morrison
Jonas L. Steinhäuser
Selected Publications
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Neural circuits of interoception. Berntson GG, Khalsa SS. Trends in Neurosciences 2021 Jan;44(1):17-28. doi: 10.1016/j.tins.2020.09.011. PMID: 33378653.
A Bayesian computational model reveals a failure to adapt interoceptive precision estimates across depression, anxiety, eating, and substance use disorders. Smith R, Kuplicki R, Feinstein JS, Forthman KL, Stewart JL, Paulus MP, Tulsa 1000 Investigators, Khalsa SS. PLoS Computational Biology 2020 Dec 14;16(12):e1008484. doi: 10.1371/journal.pcbi.1008484. PMID: 33315893.
Reduced environmental stimulation in anorexia nervosa: An early-phase clinical trial. Khalsa SS, Moseman SE, Yeh HW, Upshaw V, Persac B, Breese E, Lapidus RC, Chappelle S, Paulus MP, Feinstein JS. Front Psychol. 2020 Oct 6; 11:567499.
An Active Inference Approach to Interoceptive Psychopathology. Paulus MP, Feinstein JS, Khalsa SS. Annu Rev Clin Psychol. 2019 May 7;15:97-122.
Interoception and Mental Health: a Roadmap. Khalsa SS, Adolphs R, Cameron OG, Critchley HD, Davenport PW, Feinstein JS, Feusner JD, Garfinkel SN, Lane RD, Mehling WE, Meuret AE, Nemeroff CB, Oppenheimer S, Petzschner FH, Pollatos O, Rhudy JL, Schramm LP, Simmons WK, Stein MB, Stephan KE, Van Den Bergh O, Van Diest I, von Leupoldt A, Paulus MP, Interoception Summit 2016 Participants. Biological Psychiatry Cognitive Neuroscience and Neuroimaging. 2018; 3: 501-13.
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Computational models of interoception and body regulation. Petzschner FH, Garfinkel SN, Paulus MP, Koch C, Khalsa SS. Trends in Neurosciences 2021 Jan;44(1):63-76. doi: 10.1016/j.tins.2020.09.012. PMID: 33378658
Cardiac sympathetic denervation and mental health. Khalsa SS, Clausen AN, Shahabi L, Sorg J, Gonzalez SE, Naliboff B, Shivkumar K, Ajijola O. Autonomic Neuroscience (in press).
Heightened affective response to perturbation of respiratory but not pain signals in eating, mood, and anxiety disorders. Lapidus RC, Puhl M, Kuplicki R, Stewart JL, Paulus MP, Rhudy JL, Feinstein JS, Khalsa SS, Tulsa 1000 Investigators. PLoS One. 2020 Jul 15; 15(7):e0235346.
Somatomap: A novel mobile tool to assess body image perception, piloted with fashion models and non-models. Ralph-Nearman C, Arevian AC, Puhl M, Kumar R, Villaroman D, Suthana N, Feusner JD, Khalsa SS. JMIR Ment Health. 2019 Oct 29;6(10):e14115.
Interoceptive anxiety and body representation in anorexia nervosa. Khalsa SS, Hassanpour MS, Strober MA, Craske MG, Arevian AC, Feusner JD. Frontiers in Psychiatry. 2018 Sep 21;9:444.
The hierarchical basis of neurovisceral integration. Smith R, Thayer JF, Khalsa SS, Lane RD. Neuroscience and Biobehavioral Reviews. 2017; 75: 274–296.
What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa. Khalsa SS, Portnoff LC, McCurdy-McKinnon D, Feusner JD. Journal of Eating Disorders. 2017; 5: 20.
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Diminished responses to bodily threat and blunted interoception in suicide attempters. DeVille DC, Kuplicki R, Stewart JL; Tulsa 1000 Investigators, Aupperle RL, Bodurka J, Cha YH, Feinstein J, Savitz JB, Victor TA, Paulus MP, Khalsa SS. Elife. 2020 Apr 7;9. pii: e51593. doi: 10.7554/eLife.51593. PMID: 32254020. IF: 7.1
The practice of meditation is not associated with improved interoceptive awareness of the heartbeat. Khalsa SS, Rudrauf D, Hassanpour MS, Davidson RJ, Tranel D. Psychophysiology. 2020 Feb;57(2):e13479.
The insular cortex dynamically maps changes in cardiorespiratory interoception. Hassanpour MS, Luo Q, Feinstein JS, Simmons WK, Bodurka J, Paulus MP, Khalsa SS. Neuropsychopharmacology. 2018; 43, 126-131.
Clinical Neurocardiology—defining the value of neuroscience based cardiovascular therapeutics.
Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler MD, DeFerrari G, Fishbein MC, Goldberger JJ, Harper RM, Joyner MJ, Khalsa SS, Kumar R, Lane RD, Mahajan A, Po S, Schwartz PJ, Somers V, Valderrabano M, Vaseghi M, Zipes D. Journal of Physiology. 2016 Jul 15;594(14):3911-54. Panic anxiety in humans with bilateral amygdala lesions: pharmacological induction via cardiorespiratory interoceptive pathways. Khalsa SS, Feinstein JS, Wi L, Feusner JD, Adolphs R, Hurlemann R. The Journal of Neuroscience. 2016; 36(12): 3559-3566..
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The Tulsa 1000: A naturalistic study protocol for multi-level assessment and outcome prediction in a large psychiatric sample. Victor TA, Khalsa SS, Simmons WK, Feinstein JS, Savitz J, Aupperle RL, Yeh H, Bodurka J, Paulus MP. BMJ Open. 2018; 7:e016620.
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Research Collaborators
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Olujimi Ajijola, M.D., Ph.D.
University of California- Los Angeles Armen Arevian, M.D., Ph.D.
University of California- Los Angeles Karl-Jürgen Bär, M.D.
University of Jena Ilona Croy, Ph.D.
University of Jena |
Paul Fletcher, M.B.B.S.
Cambridge University Rene Hurlemann, M.D., Ph.D.
University of Oldenburg Walter Kaye, M.D.
University of California- San Diego Gang Chen, Ph.D.
National Institute of Mental Health |
Wesley Thompson, Ph.D.
University of California- San Diego |
