Plasticity of Aversive Salience in Opioid Use Disorder (PASO)

The Plasticity of Aversive Salience in Opioid Use Disorder (PASO) study is a five year project funded by the National Institute on Drug Abuse (NIDA; grant # R01DA050677) to better understand the process of early recovery from opioid addiction (the first three months after entering treatment). People struggling with opioid addiction experience heightened stress, drug craving/urges, aversive bodily sensations, and negative emotions including depression, anxiety, pain, and suicidal thoughts when trying to quit drugs and stay abstinent. We want to understand how clinical symptoms, behavior, brain function, and physiology change during early recovery and predict who has success remaining abstinent the first three months post-treatment. We hope that knowledge from the PASO study will aid in the development of new intervention targets for opioid addiction. We have partnered with 12&12 Inc. and Women In Recovery to recruit individuals in their treatment programs for the PASO study.  

---

The PASO Team

Jennifer Stewart
Principal Investigator
​LIBR

Rajita Sinha
​Consultant, Yale University

Rayus Kuplicki
​Co-Investigator
​LIBR

Chrysantha Davis
​Study Coordinator

Martin Paulus
Co-Investigator
LIBR

Natosha Markham
Clinical Research Interviewer

Henry Yeh
​Consultant
​Kansas City Children’s Hospital

Mariah Nacke
Research Assistant

---