PASO - Laureate Institute for Brain Research

Plasticity of Aversive Salience in Opioid Use Disorder (PASO)

The Plasticity of Aversive Salience in Opioid Use Disorder (PASO) study is a five year project funded by the National Institute on Drug Abuse (NIDA; grant # R01DA050677) to better understand the process of early recovery from opioid addiction (the first three months after entering treatment). People struggling with opioid addiction experience heightened stress, drug craving/urges, aversive bodily sensations, and negative emotions including depression, anxiety, pain, and suicidal thoughts when trying to quit drugs and stay abstinent. We want to understand how clinical symptoms, behavior, brain function, and physiology change during early recovery and predict who has success remaining abstinent the first three months post-treatment. We hope that knowledge from the PASO study will aid in the development of new intervention targets for opioid addiction. We have partnered with 12&12 Inc. and Women In Recovery to recruit individuals in their treatment programs for the PASO study.

About 12 & 12 Inc.

12&12, Inc. is the largest Comprehensive Community Addiction Recovery Center in Oklahoma. At 12&12, our only focus is to help men and women battle the brain disease of addiction and co-occurring substance abuse/mental health disorders. Our complete continuum of care provides multiple levels of treatment including detoxification, intensive residential treatment, outpatient and intensive outpatient treatment, counseling, transitional living, and sober living.

For over 35 years, we have helped thousands of Oklahomans in the fight to get their lives back. Our service model is based on a multi-disciplinary approach that integrates medical oversight, psychiatry, nursing, counseling and case management.

Independently operated and located in the heart of Tulsa, we have Behavioral Health Care accreditation from the Joint Commission, and are certified by the Oklahoma Department of Mental Health and Substance Abuse Services (ODMHSAS) as a Comprehensive Community Care Addiction Recovery Center (CCARC). For more information on 12&12, Inc. visit www.12and12.org.

About Women in Recovery

Women in Recovery (WIR) is an intensive outpatient alternative for eligible women facing long prison sentences for non-violent drug-related offenses. Operated in partnership with the George Kaiser Family Foundation, WIR works closely with the criminal justice system and various community partners to ensure program participants receive supervision, substance abuse and mental health treatment, education, workforce readiness training and family reunification services. Benefits:

Strengthens individuals and families
Breaks the cycle of intergenerational incarceration
Helps women involved in the criminal justice system become productive, tax-paying citizens
Is more cost-effective than incarceration
Improves public safety

Addiction, abuse and poverty are factors that impact the vast majority of WIR participants. We help women conquer their drug addiction, recover from trauma and acquire the essential economic, emotional and social tools to build successful and productive lives. WIR is designed for women who are dedicated to changing their lives and becoming positive, contributing members of our community.