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Maëlle Gueguen, Ph.D.


Associate Investigator, LIBR
​Addiction Services Liaison Officer, LIBR
Research Assistant Professor, Oxley College of Health and Natural Sciences, The University of Tulsa

CURRICULUM VITAE
GOOGLE SCHOLAR

The Gueguen Laboratory


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Our Research Approach


Dr. Gueguen's laboratory employs behavioral, neuroimaging and computational modeling techniques to investigate the neurocomputational mechanisms underlying maladaptive appetitive and aversive outcome processing in Substance Use Disorders, how they are linked to mood and affective states and how they can lead to drug reuse. A major overarching goal is to identify actionable behavioral intervention targets to promote long-term abstinence. Dr. Gueguen's research is funded in part by Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence (CoBRE) grant (5P20GM121312-07).

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CONTACT DR. GUEGUEN
APPLY TO BE A RESEARCH ASSISTANT

Research Program Highlights


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Main Questions
How do people with Substance Use Disorders respond to aversive events? How can a negative internal state of anxiety or withdrawal affect their sensitivity to aversive events associated with drug use? Are they always able to learn how to adapt their behavior to avoid experiencing negative consequences associated with drug use? 

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Approach​​
We apply computational modeling to behavioral and neuroimaging experiments probing cognitive processes involved valuation, appetitive and aversive outcome processing and reinforcement learning in populations with Substance Use Disorders. ​

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Future Directions​​
​The lab's next project aims to tease apart maladaptations in the sensitivity to aversive events from altered abilities to learn from these events, in people with Substance Use Disorders. This will further our understanding of why many individuals continue to use drugs despite being aware of the negative consequences associated with sustained drug use. This knowledge could be leveraged to improve the effectiveness of behavioral interventions promoting abstinence. 

Scientific Background


Dr. Gueguen grew up in the French Alps. She received her B.Sc in Biology and M.Res in Neurobiology and Neuroscience from the University Grenoble Alpes (UGA), then pursued her graduate studies in Cognitive Neuroscience at the Grenoble Institute for Neuroscience under the joint supervision of Dr. Julien Bastin (UGA) and Dr. Jean-Philippe Lachaux (Lyon Neuroscience Research Center). Her graduate work focused on identifying the cortical correlates of reinforcement learning. Using intracortical electrophysiological recordings in humans and computational modeling, her work identified the neural signatures responsible for reward-seeking and punishment-avoidance, and proved the co-existence of distinct cortical circuits encoding prediction errors and their components. 
 
In 2020, Dr. Gueguen joined Rutgers University (New Jersey, USA) to complete a 3.5-year postdoctoral fellowship with Dr. Anna B Konova in Addiction and Decision Neuroscience. During her fellowship, she designed and ran behavioral and neuroimaging studies focused on understanding maladaptive value-based decision-making in populations with Substance Use Disorders. She leveraged the use of computational modeling to identify time-sensitive effects of drug use on reward valuation and representation, attitudes towards risk and ambiguity, and mood and affective states. 
 
Dr. Gueguen joined LIBR in 2023 as an Associate Investigator, working closely with Dr. Martin Paulus, Dr. Jennifer Stewart and Dr. Ryan Smith, where she is using computational modeling to probe cognitive processes, measure their possible maladaptations and provide targets for intervention in maladaptive appetitive and aversive processing in Substance Use Disorders. 
 
In the past decade, Dr. Gueguen has had the chance to teach biology and biochemistry to over 250 students, as well as mentor a dozen undergraduate and graduate students on cognitive experiments, computational modeling, sEEG and fMRI methodology, data collection/analysis, and scientific communication. She is always happy to talk about science and aspires to empower junior scientists to develop their skills and discover their own career path. 

Meet Our Team


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Sarah Qundes
Research Assistant
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Rachel Thompson
Summer Research Volunteer

Selected Publications


Gueguen MCM, Schweitzer EM, Konova AB. Computational theory-driven studies of reinforcement learning and decision-making in addiction: What have we learned? Curr Opin Behav Sci. 2021 Apr;38:40-48.
Collomb-Clerc A*, Gueguen MCM, Minotti L, Kahane P, Navarro V, Bartolomei F, Carron R, Regis JM, Chabardès S, Palminteri S, Bastin J (2023). Human thalamic low-frequency oscillations correlate with expected value and outcomes during reinforcement learning. Nature Communications 14, 6534. DOI: https://doi.org/10.1038/s41467-023-42380-6
Gueguen MCM, Lopez-Persem A, Billeke P, Lachaux JP, Rheims S, Kahane P, Minotti L, David O, Pessiglione M, Bastin J. Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans. Nat Commun. 2021 Jun 7;12(1):3344. DOI: 10.1038/s41467-021-23704
Pouchon A, Vinckier F, Dondé C, Gueguen MCM, Bastin J, Polosan M (2023). Reward and punishment learning deficits among bipolar disorder subtypes. Journal of Affective Disorders, 340, 694-702.
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FULL LIST OF PUBLICATIONS

Research Collaborators


Anna B Konova, Ph.D.
​
Rutgers University
Intercultural Cognitive Network
Stefano Palminteri, Ph.D.
ENS Paris
Hernan Anlló, Ph.D.
ENS Paris
COLLABORATE WITH DR. GUEGUEN
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        • HANNAH BERG
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