 The research of Dr. Martin Paulus, Scientific Director and President of Laureate Institute for Brain Research (LIBR) focuses on three main areas:
Q: You recently co-authored a review (Screen Media Activity in Youth: A Critical Review of Mental Health and Neuroscience Findings) that looks at the relationship between screen media activity (SMA), mental health, and brain processes. What are researchers finding that will be most useful to parents? A: As parents, it's crucial to be aware of how Screen Media Activity (SMA) - time spent on screens like TVs, computers, mobile phones, and video games - can affect your child's mental health and overall well-being. One of the most important research findings involves the how SMA affects sleep. Excessive time spent on screens, particularly watching videos and playing video games, can negatively impact your child's sleep. This includes shorter sleep times and more difficulty falling asleep. It's particularly important for young girls who spend a lot of time on their smartphones, as they're more likely to have sleep problems. Consider setting boundaries for screen time, especially before bed, to help ensure a good night's sleep. Q: Some parents say when their kids spend a lot of time online it affects their mood. Do the research findings support this? A: Researchers have found that spending too much time on screens can increase the risk of emotional problems like depression and anxiety in children and teenagers. Using social media for extended periods can also lead to increased feelings of family conflict and reduced support from friends and family. Be aware of your child's online habits and ensure they have plenty of opportunities for offline social interactions. Q: The relationship between screen time and attention or thinking skills isn’t exactly straightforward. Can you share what that means for parents? A: Some studies suggest that playing video games might improve attention, but more research is needed. Importantly, juggling multiple forms of media at the same time - like texting while watching TV - can be associated with issues like impulsiveness and lower working memory but it is not clear from the research which is cause and which is consequence. Nevertheless, I would suggest to encourage your child to focus on one activity at a time. Q: What are some other SMA effects researchers are studying? A: The effects of screen time can vary widely. For instance, more screen time can be linked to unhealthy eating habits and weight gain, lower emotional understanding, and poorer academic performance. But, it doesn't necessarily mean your child will be less physically active. Interestingly, watching TV and playing video games can affect children and teenagers differently. Excessive screen time has also been linked to a range of behavioral and learning issues. It's important to monitor your child's screen time and encourage a range of activities beyond screens. In summary, while technology is a part of our lives and can have benefits, excessive screen time can have negative impacts on various aspects of your child's life. Balance is key. Encourage a variety of activities - both online and offline - and set healthy boundaries around screen time. Keep an eye on your child's behavior and step in if you notice any issues. As always, if you're worried about your child's mental health or behavior, don't hesitate to seek professional help.
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 As a principal investigator and Director of Native American Research and the Electroencephalography Core for LIBR, Dr. Evan White, Ph.D. dedicates much of his professional effort to working with American Indian communities to advance mental health. The focus of his work is employing clinical neuroscience to improve mental health outcomes among AI communities—in particular, his research looks at two things: cultural engagement and the role it may play in providing protection against poor mental health outcomes; he also works to identify the signatures of those cultural protective factors that may enhance culturally informed prevention and intervention efforts.
How does your work help advance health equity? What are you seeing in the American Indian communities? In the scope of mental health studies, our work is very much in the early stages. Unfortunately, many mental health disparities among American Indian (AI) populations remain and are potentially even growing. We have not observed changes in health disparities attributable to the research we’re doing; however, this work is advancing health equity in important ways. Native populations are vastly underrepresented in clinical neuroscience research, particularly as a population of focus. We are working to remedy this by placing AI communities at the center of our clinical-cultural neuroscience research, and by building community partnerships to collaborate in our research process. The broader goal is to incorporate principles from community-engaged research methods (Community-Based Participatory Research/CBPR in particular) whenever possible. It’s important to note that this endeavor is not unique to our research, and encouragingly, our research is informed by a substantial and growing body of health equity researchers who champion community-grounded health equity research. What are your research goals, purpose and aim? My research aims to establish and advance a neuroscientific understanding of cultural factors that are protective against poor mental health among American Indians (AI) utilizing a strength-based framework. My goal is to integrate clinical and cultural neuroscience to identify modifiable factors as candidate treatment targets for mental health intervention and prevention. We are working to establish a clinical-cultural-neuroscience framework in which mental health intervention and prevention efforts are culturally grounded, community-engaged, and guided by neuroscience. You are an enrolled member of the Absentee Shawnee Tribe of Oklahoma. Does your identity as a tribal member inspire you to research minority health, health disparities, and health equity? Improving the health and wellbeing of the populations we serve is a motivation many researchers share, and my commitment to helping the community I come from is no exception. However, my motivation extends to other communities and populations that also experience disparities and it is my hope that our work can make a meaningful impact at home and more broadly. In the scientific and medical communities, it is a well-known fact that minority communities are disproportionately impacted by mental health risk factors and, as a result, mental health conditions. Like many native people, I have seen first-hand the impacts of suicide, substance misuse, and addiction. As health disparities researchers we can play an important role in helping to address these conditions. On a positive note, I have also seen the incredible strengths and resilience of Native people and communities rooted in relationships and traditional cultural practices and values. I believe this is a critically important area for mental health disparities research – a community-grounded understanding of treating and preventing disparate mental health conditions which leverages and elevates the strengths that exist within communities. Are there any studies you’re recruiting for right now? What type of volunteers do you need? Are volunteers paid, and what’s involved in being a volunteer? We are always interested in people willing to participate in our research studies. Individuals who participate are compensated for their time and can expect to answer questions related to their health and general life experiences. If individuals qualify for one of our studies based on a variety of factors, they may be contacted to complete some additional protocols that include interviews, computer tasks and even brain scanning. This is a big question: How do we encourage the next generation of scientists? I know that for me, I received encouragement to pursue my passion from supportive mentors, training programs, colleagues, and family and friends outside of academia. The support I am given helps me find ways to encourage the next generation of scientists. We need to engage students with hands-on research opportunities early in their training—and not just data collection and curation—but also with idea development, generating research questions, analytic training, and opportunities to share and present findings with a broad audience. Providing training like this in an inclusive and growth-oriented environment allows trainees to explore and develop their own passions for research. We have created these experiences at LIBR in recent years with the LIBR Accelerated Summer Research Internship and Diversity, Research, and Mental Health Neuroscience (DReaM-Neuro) fellowship programs. Dr. Steven Cole - May 2, 2023
"Social Regulation of Human Gene Expression" William K. Warren, Jr. Frontiers in Neuroscience Lecture 12:00 pm - 1:00 pm Program in the LPCH auditorium (No registration needed) Steven Cole is a Professor of Psychiatry & Biobehavioral Sciences and Medicine in the Division of Hematology-Oncology at the David Geffen School of Medicine at UCLA. His research utilizes molecular genetics and computational bioinformatics to analyze the pathways by which social and environmental factors influence the activity of the human genome, as well as viral and cancer genomes. He pioneered the field of human social genomics, and discovered the "Conserved Transcriptional Response to Adversity" that mediates health disparities via neural regulation of inflammatory genes and antiviral genes in monocytes. He serves as Director of the UCLA Social Genomics Core Laboratory, and is a member of the Jonsson Comprehensive Cancer Center, the Norman Cousins Center, the UCLA AIDS Institute, the UCLA Molecular Biology Institute, and a Fellow of the American Association for the Advancement of Science. Learning objectives:
Saint Francis Health System designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. For Psychologists: The Oklahoma State Board of Examiners of Psychologists, the American Psychological Association and the Oklahoma Psychological Association recognize AMA PRA Category 1 credit™. Saint Francis Health System is accredited by the OSMA For Social Workers: Saint Francis Health System is an approved provider of continuing education for social worker through the Oklahoma State Board of Licensed Social Workers for 1 hour Category 1 Clinical. (CEP Number - 20230007) For CADCs and LADCs Saint Francis Health System is accredited as a provider of continuing education programs for CADCs and LADCs through the Oklahoma Board of Licensed Alcohol and Drug Counselors. (1 hour)
 Dr. Salvador Guinjoan is a Principal Investigator at LIBR and Research Associate Professor at The University of Tulsa. He is working on the definition of neurobiological signatures of transdiagnostic clinical manifestations (especially rumination, a well-known adverse prognostic factor in a variety of psychiatric conditions), with the purpose of attaining a better definition of both 1) disease processes which transcend current psychiatric diagnostic categories, and 2) prognosis and prediction of response to treatment, especially in the mood and anxiety disorders. To this end, he is studying a large sample of healthy participants and patients with nonpsychotic disorders (T1000). He is also helping to define experiments that characterize -and modulate- structural and functional brain circuits in such disorders, with the ultimate goal of providing the treating clinician with diagnostic and prognostic tools based upon quantifiable neurobiological variables.
What is your research study about? We are using a new technique called low-intensity focused ultrasound, which allows us to modulate the activity of small and well-defined areas in the brain using a non-invasive brain scan. Our goal is to define brain circuits that sub-serve our behaviors, thoughts, and emotions. In particular, we are interested in modulating brain connections involved in rumination. Rumination is a repetitive pattern of thinking, primarily self-relevant negative thoughts and memories. Rumination is associated with more difficult treatment of depression. If we were able to resolve it, in theory, we could also improve the prognosis of depression in general. What is focused ultrasound? Focused ultrasound is a novel technique to influence the activity (or the structure) of areas anywhere in the brain, in a non-invasive, painless, and safe way. We are only using low-intensity focused ultrasound, which modulates brain activity for a relatively short period of time. Alternatively, when used with high intensity in a neurosurgery setting, focused ultrasound can produce well-defined, circumscribed lesions in circuits that have been demonstrated to improve neurological conditions such as Parkinson’s disease and essential tremor, which might be useful in psychiatric conditions such as obsessive-compulsive disorder and major depression. Low-intensity and high-intensity ranges are well-defined and, in fact, use different devices. Again, we only use low-intensity focused ultrasound. How is the study being conducted? Participants in the study undergo an initial eligibility evaluation. Eligible participants include healthy, unmedicated persons, as well as persons with depression and varying degrees of rumination as one of the symptoms of their depression. The initial evaluation includes measuring a series of clinical variables and obtaining brain images with a magnetic resonance (MRI) scanner. Subjects return for two more visits, in which each participant undergoes either low-intensity focused ultrasound of connections between two areas of the brain, or a sham procedure (neither the participant nor the clinical rater know which kind of procedure occurs in each visit). Immediately after low-intensity focused ultrasound or sham, the person is asked to complete questionnaires about the extent of their ruminations, and how they feel in general. We also obtain measures of cardiac and skin regulation, and another series of brain images. What is the potential importance of this study? The goal of the study is to define if the brain connections targeted with low-intensity focused ultrasound are the cause of rumination. This is why we need to obtain information about both the symptom itself and the brain activity. If we confirm a relationship between certain brain connections and the production of rumination, this would pave the way to a clinical trial. This trial, performed in a clinical setting, would confirm that we can actually help patients with depression to become less ruminative. For this, we could use focused ultrasound or other forms of neuromodulation. The most important thing is characterizing the brain region involved in the symptom, rather than which tool we use to alter its function. Are you looking for participants? If so, who is the ideal candidate? Yes, we are actively recruiting participants. This is a pilot study, meaning we plan to recruit a relatively small number of participants. Currently, there are just 20 slots remaining. Any person with active depression who is not pregnant or actively using drugs, and who can be scanned, is eligible to participate. Persons who either very ruminative or not ruminative are eligible, as we need to know if there is a difference between the two. A small proportion of those 20 slots will be reserved for persons with no known psychiatric conditions, so healthy adults are also eligible to participate. What does participation in the study involve? And will I be paid? The study consists of a total of five visits. Visit 1 is for clinical evaluation and brain images. Visits 2 and 4, which occur about two weeks apart, are for assessing the effect of low-intensity focused ultrasound in comparison with sham stimulation. Between those visits, Visit 3 is short and basically used to see how the participant is doing after the first treatment (be it active or sham). Visit 5 is an opportunity to wrap up the study, in which we again check on the general mental status and brain structure. All participants will be paid for their time spent in the study. The 2022 Laureate Institute for Brain Research (LIBR) Annual Report is now available to download via the link below. The report provides an overview of last year’s happenings at LIBR, including a letter from the President and Scientific Director, Dr. Martin Paulus, information on our mission, history and specific aims, current areas of research, funding sources, events and lectures, awards, individual laboratories, select publications and opportunities to participate in research. We hope you enjoy the publication and look forward to continuing our goal to improve mental health through neuroscience in 2023 and beyond.  The Oklahoman has published a op-ed piece from Dr. Martin Paulus, Sahib Khalsa and Salvador Guinjoan on what Oklahomans should consider from the latest marijuana research ahead of SQ 820.
Dr. Sahib Khalsa, M.D., Ph.D., is Director of Clinical Operations for LIBR, Associate Professor at the Oxley College of Health Sciences at the University of Tulsa, Director at LIBR Float Clinic and Research Center, and Volunteer Faculty Member in the Department of Psychiatry at the University of Oklahoma. Dr. Khalsa’s laboratory studies the role of the brain-body connection in human health; he has published more than 90 peer-reviewed papers and has received research funding from the National Institute of Mental Health (NIMH), National Institute for General Medical Sciences (NIGMS), National Center for Complementary and Integrative Health (NCCIH), the NIH/National Center for Advancing Translational Science (NCATS), the Mind and Life Foundation, and the Brain and Behavior Research Foundation. His research is currently funded by NIMH and LIBR.
Q: The Laureate Psychiatric Hospital and LIBR are known and respected for their work in the fields of identifying, treating, and researching eating disorders like anorexia nervosa; as February is focused on heart health, how does what you study relate to a healthy heart? A: Many people know about the relaxing experience of floating in water or the value of taking some time each day to pause and be away from the usual hustle and bustle of daily activities. We are currently studying the potential therapeutic impact of a particular form of Reduced Environmental Stimulation Therapy (REST) called Floatation-REST, on mental health in individuals with anxiety disorders, depression, eating disorders, or substance use disorder. Floatation-REST reduces external sensory input to the central nervous system by minimizing environmental stimulation, through the act of floating supine in a pool of water saturated with Epsom salt. In this environment, the density of the salt water allows for effortless floating. The temperature of the air and water is matched to the person’s skin temperature, and visual and auditory stimulation and movement is minimized. Our research using Floatation-REST (Paper 1) (Paper 2) has shown that it can significantly reduce blood pressure during the float session, especially the diastolic blood pressure, reduce breathing rate, and certain metrics of heart rate variability, suggesting a shift in the autonomic nervous system toward a more relaxed state. Interestingly, Floatation-REST is also associated with enhanced awareness for cardiac and respiratory sensations while reducing anxiety levels in anxious individuals, indicating a paradoxical effect. We have also recently found that Floatation-REST acutely lowers anxiety and stress symptoms and improves some aspects of body image in hospitalized individuals with anorexia nervosa. Q: How do your present studies take the next steps in studying heart health as it relates to eating disorders? A: Our ongoing studies are adding to the rigor of prior research by thoroughly characterizing the cardiovascular changes induced by Floatation-REST and examining how neural and physiological changes are associated with its anxiolytic effects. For example, in healthy individuals, we have found that Floatation-REST is associated with a reduced functional coupling of brain activity within the hubs of brain networks most responsible for creating and mapping our sense of self. We also recently found that women with anorexia nervosa show reduced brain-body network connectivity after undergoing a cardiac stress challenge; the less connected these parts of the brain were, the more anxiety, depression, and negative body image the women had. We plan to extend these studies to identify whether changes in similar brain networks helps to explain the beneficial impacts observed with Floatation-REST in individuals with eating disorders. Q: Do you need people to help you with this new research project? A: We are conducting several studies looking at the role of the brain-body connection in eating disorders. When an individual receiving treatment with Laureate qualifies for ongoing research studies, they may be offered the opportunity to participate. The clinical team assists in evaluating how participation will support their recovery and whether the individual might benefit from engaging in the study. We also need volunteers not in treatment for an eating disorder to help with this research. If you or someone you know between the ages of 13-40 would like to be one of our paid volunteers, please contact our lab or fill out the form on our website. Dr. Joan Camprodon - February 7, 2023
"Suicide Circuit Therapeutics: Leveraging the Efficacy of ECT and the Focality of TMS" William K. Warren, Jr. Frontiers in Neuroscience Lecture 12:00 pm - 1:00 pm Program in the LPCH auditorium (No registration needed) Dr. Camprodon is inaugural Chief of the Division of Neuropsychiatry and Director of the Laboratory for Neuropsychiatry and Neuromodulation at Massachusetts General Hospital, and Associate Professor of Psychiatry at Harvard Medical School. Clinically, he is the founding Director of the MGH Transcranial Magnetic Stimulation (TMS) clinical service, a member of the Psychiatric Neurosurgery Committee and an attending physician in the Departments of Psychiatry (Neuropsychiatry) and Neurology (Cognitive and Behavioral Neurology). He is board-certified in psychiatry and behavioral neurology-neuropsychiatry. Dr. Camprodon’s research focuses on Neuropsychiatry and Neuromodulation. Methodologically, he uses multimodal combinations of brain stimulation and neuroimaging/neurophysiology to investigate neural circuitry and plasticity in a translational manner. He uses a wide range of noninvasive and invasive neuromodulation techniques including transcranial current stimulation (tCS, e.g. tDCS/tACS), transcranial magnetic stimulation, transcranial photobiomodulation, electroconvulsive therapy and deep brain stimulation. He also uses multimodal functional and structural MRI, EEG and innovative simultaneous combinations of TMS and tDCS/tACS with neuroimaging and neurophysiology. The scope of his research includes basic, translational and clinical projects focused on human circuit neuroscience. Projects in his laboratory address (1) circuit level neuropsychiatric pathophysiology (with an emphasis on transdiagnostic processes and the role of plasticity) and (3) the translational development of tools to support clinical care and decision-making (e.g. biomarkers and treatment development). Critical efforts are geared towards applying the paradigms and methods of human systems/cognitive neuroscience to discover treatment targets that support the development of individualized precision therapeutics, with a focus on image-guided device-based neuromodulation. Learning objectives:
Saint Francis Health System designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. For Psychologists: The Oklahoma State Board of Examiners of Psychologists, the American Psychological Association and the Oklahoma Psychological Association recognize AMA PRA Category 1 credit™. Saint Francis Health System is accredited by the OSMA For Social Workers: Saint Francis Health System is an approved provider of continuing education for social worker through the Oklahoma State Board of Licensed Social Workers for 1 hour Category 1 Clinical. (CEP Number - 20230007) For CADCs and LADCs Saint Francis Health System is accredited as a provider of continuing education programs for CADCs and LADCs through the Oklahoma Board of Licensed Alcohol and Drug Counselors. (1 hour) The LPC/LMFT This event as been approved by the State Board of Behavioral Health Licensure (BBHL) for 1 hour of CE. For questions , email: Lauren Haguewood at lehaguewood@saintfrancis.com  Now that the initial fervor of New Year’s Resolutions has passed, you have plenty of time to consider what is most meaningful to you and develop goals that may truly fit with those values.
We talked with LIBR principal investigator Dr. Robin Aupperle about how to combat the tendency of people to abandon their January 1 resolutions—and instead use SMART goals to make lasting life changes. Q: How are SMART goals different from something like a New Year’s resolution? RA: Good question. There’s a tremendous push—internal and external—to start the New Year with a big, transformative resolution. For instance, I’ve heard resolutions like “I’m going to work out every single day this year,” “I’m going to save 50% of my salary,” or “I’m going to lose 50 pounds,” none of which are likely to be realistic. Some of these goals may also relate to what people feel they “should” do rather than necessarily being related to what is truly important for that individual. Q: Those seem lofty, but if we don’t try, we’ll never do it, right? RA: It can be very challenging to change our behaviors and ingrained habits. In order to be successful, the new behaviors have to be rewarding and reinforcing in some way. This feeling of reward can come from feeling successful and accomplished for being successful, or from engaging in something we value and enjoy. Q: What’s a better approach? RA: SMART goals offer a great framework for how to think about goal-setting. SMART is an acronym that helps identify and quantify elements of the goal you’re setting. Q: How does that work? RA: SMART stands for: S Specific What is the specific goal that someone wants to accomplish? “I want to increase my stamina and endurance so that I feel healthier.” M Measurable What data will be used to measure the goal? How will I measure it? “I will start by doing something that raises my heart rate for 20 minutes two times a week. My long-term goal will be to work towards 30 minutes, three times per week. I’ll make a calendar to chart my progress and keep myself accountable.” A Achievable Is the goal doable? Do you have the necessary skills and resources? “I will walk around my neighborhood (around the office, or at the mall) after work on Mondays and Thursdays, inviting friends to join me.” R Relevant How does this goal align with your values? Why is the result important? “I know I need to be less sedentary for my health. I want to be healthier in order to feel like I have more energy throughout my daily life and live longer.” T Time-Bound What’s the timeframe for accomplishing this goal, beginning to end? “I will focus on 20 minutes, two times a week for two months and assess my progress and modify my goals as needed.” Q: That’s a lot of work! RA: Much of this relates to all the thoughts going on in our heads when we are considering behavior change. This just provides a framework for organizing these thoughts, and making them specific. The main idea though, is that any attempts at change offer helpful information. If you aren’t successful in your first attempts, the key is to not get down on yourself! Simply consider what obstacles got in the way and how you can modify your plan to be more effective. For example, this could include starting smaller and breaking things down – for example, starting with walking around the block ONE time, ONCE per week to begin with….and then working up from there. Any amount of successful change goes a long way towards motivating further change. The University of California created this SMART goals template—it’s really good. You can use it to write your own SMART goals: Initial Goal (Write the goal you have in mind): ______________________________________________________________________________ 1. Specific (What do you want to accomplish? Who needs to be included? When do you want to do this? Why is this a goal?) ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ 2. Measurable (How can you measure progress and know if you’ve successfully met your goal?): ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ 3. Achievable (Do you have the skills required to achieve the goal? If not, can you obtain them? What is the motivation for this goal? Is the amount of effort required on par with what the goal will achieve?): ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ 4. Relevant (Why am I setting this goal now? Is it aligned with overall values?): ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ 5. Time-bound (What’s the deadline and is it realistic?): ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ S.M.A.R.T. Goal (Review what you have written, and craft a new goal statement based on what the answers to the questions above have revealed): ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Q: Do you have any SMART goals you’re working on? RA: I am working towards building strength by focusing on lifting weights when I am at the gym. My initial goal is to go twice per week for 30 minutes each time. I am going to re-assess my goals in two months to consider if I should modify my goal. This is important to me because I want to be stronger to keep up with my kids, who are very into ninja warrior right now! I also have non-health related goals, such as writing a children’s book, which I have broken down into several steps needed to work towards that goal. Dr. Aupperle has initiated research projects at LIBR investigating neurocognitive and behavioral predictors of treatment response to behavioral activation therapy for depression and exposure therapy for anxiety. In addition, she is taking the lead in LIBR projects investigating predictors of success for females enrolled in a criminal diversion program and factors related to mental health resiliency in college students. |
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