Welcome from the Director
Martin Paulus, M.D.
President and Scientific Director
"Since arriving at LIBR in 2014, I have been enormously energized by the opportunity to make a real difference using neuroscience to improve the life of patients with mental illness. At the same time, I recognize this is a very challenging task, which cannot be accomplished overnight. However, with a thoughtful eye on what is doable, we are hoping to make a measureable impact on ways to assess and treat patients within five years.
We have started a major study in 2015, the Tulsa 1000, or T-1000. The goal for this study is to determine whether neuroscience-based measures can be used to predict outcomes in patients with mental illness. In particular, we are trying to determine what factors best predict who will respond well to a particular treatment. The study is a definitive step towards developing a science-based personalized medicine approach in mental health. Unfortunately, mental health treatment providers are still using guesswork and intuition in matching treatments to patients. As a consequence mental health treatment is fundamentally a trial and error endeavor, which can result in prolonged suffering if treatments do not work. The hope is that we will be able to use scientific approaches to more precisely match patients to treatments."
Meet the Investigators
Kyle Simmons, Ph.D.
Why is it that some individuals lose their appetite when they get depressed, and others eat more? Can these changes in eating behavior be used as an early indicator of depression onset, improvement, or recurrence?
We use sophisticated behavioral, endocrine, and functional brain imaging techniques and analyses to determine what brain mechanisms underlie changes in eating behavior in depression, and whether these changes are leading or lagging indicators of illness onset and recovery.
Activity signatures in brain regions important for the crosstalk between the brain and body distinguish between depressed individuals who eat too much and those who eat too little.
To develop approaches that can be used to predict the course of depression based on changes in the body-brain connection in general, and regulation of eating in particular.
Dr. Simmons is currently Assistant Professor at LIBR and the School of Community Medicine at the University of Tulsa, OK.
What's New & Noteworthy
TIME Feature on Resilience
Dr. Martin Paulus' work on resilience with several Marine infantry platoons and Olympic BMX athletes has been featured in the article "The Science of Bouncing Back" as part of the Frontiers of Medicine section in TIME Magazine.
Risk-Prediction Model for Clinical Psychiatry
Dr. Martin Paulus has published a viewpoint article in JAMA Psychiatry that highlights the difficulties of making neuroscience useful for clinical psychiatry and advocates for a risk-prediction model in the development of impactful biological psychiatry to help patients now. LIBR's Tulsa 1000 study is based on this premise of making an impact on everyday psychiatric practice. Download the article here:
2014 LIBR Annual Report
The 2014 LIBR Annual Report has been released to the public. Download a copy of the publication here:
The William K. Warren Jr. "Frontiers in Neuroscience" Conference Series
Topic: Neurobiology of Child Abuse and Neglect
Presenter: Dr. Charles Nemeroff, M.D., Ph.D., Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences; Director, Center on Aging, University of Miami Miller School of Medicine
Where: Laureate Psychiatric Clinic and Hospital Conference Room
When: June 2, 2015 at 12 noon
To register, please call 918-494-6490 or email email@example.com.
The event is free and open to the public.
On Friday June 5th, Dr. Brian Anderson, from Johns Hopkins University, will be presenting in Conference Room A on the LIBR campus from noon to 1pm. The title of the presentation is “Linking Reward, Attention, and Psychopathology.”
On Tuesday June 23rd, Dr. Kate Fitzgerald, MD, from the University of Michigan, will be presenting in Conference Room A on the LIBR campus from 2-3pm. The title of the presentation is “Altered brain development in pediatric OCD: potential for clinical translation.”
Tulsa 1000 Update
Tulsa 1000 Project Update
At the beginning of the year, LIBR launched the groundbreaking new Tulsa 1000 (T-1000) study. Forty-two participants have completed the first series of study visits and 20 more are scheduled into May and June. New participants are continuing to enroll each week.
The T-1000 aims to determine how biological and objective behavioral measures can improve assessment and treatment of people with disorders of mood and anxiety, eating and substance use. 1000 people from Tulsa and the surrounding areas will be recruited to enter the study.
To learn more about participating in research at LIBR, please visit our Ongoing Studies section, call 918-502-5100, or email firstname.lastname@example.org.