• HOME
  • ABOUT
    • MISSION
    • All Careers >
      • Open Faculty Positions
      • Open Post-Doctoral Positions
      • Open Scientific Positions
      • Benefits & Strengths of the Post-Doctoral Experience at LIBR
    • FELLOWSHIPS & INTERNSHIPS >
      • SUMMER INTERNSHIPS
      • LIBR/LPCH Clinical Psychology Internship
    • FUNDING SOURCES
    • COMMUNITY RESOURCES
    • MAKE A DONATION
    • CONTACT US
    • RESEARCH FAQs
  • RESEARCH
    • MRI & EEG CORE
    • LABORATORY CORE
    • DATA ANALYTICS CORE
    • ASSESSMENT CORE
    • FLOAT CLINIC & RESEARCH CENTER
    • POPULATION NEUROSCIENCE & GENETICS CENTER
    • PUBLICATIONS
  • PEOPLE
    • ALL STAFF
    • INVESTIGATORS >
      • PRINCIPAL >
        • ROBIN AUPPERLE
        • CHUN CHIEH FAN
        • LEANDRA FIGUEROA-HALL
        • SALVADOR GUINJOAN
        • MARIA IRONSIDE
        • MARTIN PAULUS
        • JONATHAN SAVITZ
        • RYAN SMITH
        • JENNIFER STEWART
        • WESLEY THOMPSON
        • EVAN WHITE
      • ASSOCIATE >
        • HANNAH BERG
        • EMILY CHOQUETTE
        • MAELLE GUEGUEN
        • MASAYA MISAKI
        • NICK OBRADOVICH
        • ADRIENNE TAREN
        • HAIXIA ZHENG
      • AFFILIATE >
        • HAMED EKHTIARI
        • SAHIB KHALSA
        • NAMIK KIRLIC
        • AKI TSUCHIYAGAITO
        • CHARLES VERDONK
      • MRI and EEG FACILITY >
        • MICHAEL ROHAN
    • ADMINISTRATIVE
    • SCIENTIFIC
    • CLINICAL & MRI ASSESSMENT
    • IN MEMORIAM
    • ALUMNI
    • SCIENTIFIC ADVISORY BOARD
  • STUDIES
    • ONGOING STUDIES
    • NEUROMAP
    • KetoSwiss
    • PASO
    • ABCD
    • RESEARCH MATCH
  • PRODUCTS
    • PRODUCTS OVERVIEW
    • NEUROIMAGING AND BEHAVIORAL TASKS
    • TULSA LIFE CHART
    • COLLEGE TOUGH RESILIENCE PROGRAM
    • BARI POSTERS
    • COVID HERO
  • NEWS
    • CURRENT EVENTS
    • FEATURED PUBLICATIONS
Laureate Institute for Brain Research
  • HOME
  • ABOUT
    • MISSION
    • All Careers >
      • Open Faculty Positions
      • Open Post-Doctoral Positions
      • Open Scientific Positions
      • Benefits & Strengths of the Post-Doctoral Experience at LIBR
    • FELLOWSHIPS & INTERNSHIPS >
      • SUMMER INTERNSHIPS
      • LIBR/LPCH Clinical Psychology Internship
    • FUNDING SOURCES
    • COMMUNITY RESOURCES
    • MAKE A DONATION
    • CONTACT US
    • RESEARCH FAQs
  • RESEARCH
    • MRI & EEG CORE
    • LABORATORY CORE
    • DATA ANALYTICS CORE
    • ASSESSMENT CORE
    • FLOAT CLINIC & RESEARCH CENTER
    • POPULATION NEUROSCIENCE & GENETICS CENTER
    • PUBLICATIONS
  • PEOPLE
    • ALL STAFF
    • INVESTIGATORS >
      • PRINCIPAL >
        • ROBIN AUPPERLE
        • CHUN CHIEH FAN
        • LEANDRA FIGUEROA-HALL
        • SALVADOR GUINJOAN
        • MARIA IRONSIDE
        • MARTIN PAULUS
        • JONATHAN SAVITZ
        • RYAN SMITH
        • JENNIFER STEWART
        • WESLEY THOMPSON
        • EVAN WHITE
      • ASSOCIATE >
        • HANNAH BERG
        • EMILY CHOQUETTE
        • MAELLE GUEGUEN
        • MASAYA MISAKI
        • NICK OBRADOVICH
        • ADRIENNE TAREN
        • HAIXIA ZHENG
      • AFFILIATE >
        • HAMED EKHTIARI
        • SAHIB KHALSA
        • NAMIK KIRLIC
        • AKI TSUCHIYAGAITO
        • CHARLES VERDONK
      • MRI and EEG FACILITY >
        • MICHAEL ROHAN
    • ADMINISTRATIVE
    • SCIENTIFIC
    • CLINICAL & MRI ASSESSMENT
    • IN MEMORIAM
    • ALUMNI
    • SCIENTIFIC ADVISORY BOARD
  • STUDIES
    • ONGOING STUDIES
    • NEUROMAP
    • KetoSwiss
    • PASO
    • ABCD
    • RESEARCH MATCH
  • PRODUCTS
    • PRODUCTS OVERVIEW
    • NEUROIMAGING AND BEHAVIORAL TASKS
    • TULSA LIFE CHART
    • COLLEGE TOUGH RESILIENCE PROGRAM
    • BARI POSTERS
    • COVID HERO
  • NEWS
    • CURRENT EVENTS
    • FEATURED PUBLICATIONS

Current Events

New Study Reveals Genetic Factors Underlying Treatment-Resistant Depression

2/26/2025

0 Comments

 
Findings Published in JAMA Psychiatry Highlight the Role of Genetic Traits in Treatment Resistance
A groundbreaking study published in JAMA Psychiatry sheds new light on the genetic factors contributing to treatment-resistant depression (TRD), a severe form of major depressive disorder that does not respond to standard treatments. Researchers from the Laureate Institute for Brain Research and collaborating institutions analyzed data from nearly 300,000 participants in the All of Us Research Program to identify genetic traits associated with TRD.

Key Findings:
  • Genetic Risk Factors for TRD: Individuals with a genetic predisposition for neuroticism, insomnia, and negative emotional temperament were more likely to develop TRD.
  • Protective Genetic Traits: Higher genetic scores for educational attainment and cognitive function were linked to a lower likelihood of developing TRD.
  • Consistent Across Populations: The results were replicated across different groups, reinforcing the role of these genetic factors in depression treatment outcomes.
  • Potential for Improved Treatments: These insights highlight the need to integrate genetic and psychological factors into personalized treatment strategies for depression.

Why This Matters
TRD affects millions of people worldwide, leading to prolonged suffering, increased healthcare costs, and higher suicide risk. While depression treatments work for many, about one-third of patients experience TRD, making it crucial to understand why some individuals do not respond to standard therapies. This study suggests that genetic predispositions influence treatment resistance, paving the way for more targeted interventions.

Expert Quotes
"Our findings emphasize that TRD is not just an extension of major depressive disorder but may have distinct biological underpinnings," said Dr. Chun Chieh Fan, the study’s senior author. "Recognizing the role of genetic factors could help refine treatment approaches and improve outcomes for those who struggle with depression."

What’s Next?
The researchers hope that these findings will inspire further studies on integrating genetics with clinical and environmental factors to develop personalized treatment plans for individuals with depression. Future research may also explore how interventions targeting neuroticism and sleep patterns could help prevent or mitigate TRD.

About the Study
The study analyzed 292,663 participants from the All of Us Research Program, a nationwide initiative collecting diverse health and genetic data. The researchers examined 61 genetic traits across various domains, including personality, cognition, sleep, and psychiatric conditions, to identify their associations with TRD.
​
For more information, access the full study in JAMA Psychiatry  here. 
0 Comments

Your comment will be posted after it is approved.


Leave a Reply.

    Archives

    June 2025
    May 2025
    April 2025
    March 2025
    February 2025
    January 2025
    November 2024
    October 2024
    July 2024
    May 2024
    April 2024
    March 2024
    February 2024
    January 2024
    December 2023
    November 2023
    October 2023
    September 2023
    August 2023
    July 2023
    June 2023
    May 2023
    April 2023
    March 2023
    February 2023
    November 2022
    October 2022
    September 2022
    August 2022
    June 2022
    May 2022
    April 2022
    March 2022
    February 2022
    December 2021
    October 2021
    August 2021
    June 2021
    May 2021
    April 2021
    March 2021
    February 2021
    January 2021
    November 2020
    October 2020
    June 2020
    May 2020
    February 2020

    Categories

    All
    Annual Reports
    From The President
    Press Releases
    Q&As
    WKW Speaker Series

    RSS Feed

VISIT LIBR

6655 South Yale Ave. Tulsa, OK 74136
​918.502.5100 | [email protected]

GET CONNECTED

Careers | Privacy Policy

Picture

© 2009-2025. All Rights Reserved. Laureate Institute for Brain Research

Site powered by Laureate Institute for Brain Research
  • HOME
  • ABOUT
    • MISSION
    • All Careers >
      • Open Faculty Positions
      • Open Post-Doctoral Positions
      • Open Scientific Positions
      • Benefits & Strengths of the Post-Doctoral Experience at LIBR
    • FELLOWSHIPS & INTERNSHIPS >
      • SUMMER INTERNSHIPS
      • LIBR/LPCH Clinical Psychology Internship
    • FUNDING SOURCES
    • COMMUNITY RESOURCES
    • MAKE A DONATION
    • CONTACT US
    • RESEARCH FAQs
  • RESEARCH
    • MRI & EEG CORE
    • LABORATORY CORE
    • DATA ANALYTICS CORE
    • ASSESSMENT CORE
    • FLOAT CLINIC & RESEARCH CENTER
    • POPULATION NEUROSCIENCE & GENETICS CENTER
    • PUBLICATIONS
  • PEOPLE
    • ALL STAFF
    • INVESTIGATORS >
      • PRINCIPAL >
        • ROBIN AUPPERLE
        • CHUN CHIEH FAN
        • LEANDRA FIGUEROA-HALL
        • SALVADOR GUINJOAN
        • MARIA IRONSIDE
        • MARTIN PAULUS
        • JONATHAN SAVITZ
        • RYAN SMITH
        • JENNIFER STEWART
        • WESLEY THOMPSON
        • EVAN WHITE
      • ASSOCIATE >
        • HANNAH BERG
        • EMILY CHOQUETTE
        • MAELLE GUEGUEN
        • MASAYA MISAKI
        • NICK OBRADOVICH
        • ADRIENNE TAREN
        • HAIXIA ZHENG
      • AFFILIATE >
        • HAMED EKHTIARI
        • SAHIB KHALSA
        • NAMIK KIRLIC
        • AKI TSUCHIYAGAITO
        • CHARLES VERDONK
      • MRI and EEG FACILITY >
        • MICHAEL ROHAN
    • ADMINISTRATIVE
    • SCIENTIFIC
    • CLINICAL & MRI ASSESSMENT
    • IN MEMORIAM
    • ALUMNI
    • SCIENTIFIC ADVISORY BOARD
  • STUDIES
    • ONGOING STUDIES
    • NEUROMAP
    • KetoSwiss
    • PASO
    • ABCD
    • RESEARCH MATCH
  • PRODUCTS
    • PRODUCTS OVERVIEW
    • NEUROIMAGING AND BEHAVIORAL TASKS
    • TULSA LIFE CHART
    • COLLEGE TOUGH RESILIENCE PROGRAM
    • BARI POSTERS
    • COVID HERO
  • NEWS
    • CURRENT EVENTS
    • FEATURED PUBLICATIONS