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The 2025 Laureate Institute for Brain Research (LIBR) Annual Report is now available to download via the link below. The report highlights the past year at LIBR, including a message from President and Scientific Director, Dr. Martin Paulus, updates on current research areas, and an overview of key initiatives and accomplishments.
This year’s report also features progress in areas such as treatment-resistant depression, neuromodulation, and large-scale population studies, as well as continued efforts to integrate neuroscience, data science, and clinical research. Readers will also find information on collaboration, training programs, select publications, and opportunities to participate in research. We hope you enjoy this year’s publication and appreciate your continued interest in LIBR’s work to advance mental health through science in 2026 and beyond.
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March 25, 2026 LIBR Researcher Dr. Adrienne Taren Unveils First Neuroscience-Based Model Linking Cumulative Occupational Trauma to Brain Changes in Frontline Workers. Tulsa, OK — Researchers at the Laureate Institute for Brain Research (LIBR) in Tulsa have published new findings that reframe how burnout in healthcare workers is understood—highlighting its roots not just in emotional strain, but in measurable changes across the brain and body. The study, published in the European Journal of Psychotraumatology, synthesizes a growing body of research on post-traumatic stress syndromes (PTSS) among frontline healthcare workers. It points to repeated, chronic exposure to high-stress environments—combined with disrupted sleep from shift work—as key drivers of cumulative physiological strain. Estimates suggest that between 15% and 74% of healthcare workers experience trauma-related symptoms, underscoring the urgency of understanding how occupational stress impacts long-term mental and physical health. Rather than viewing burnout as a temporary or purely psychological condition, the research outlines how ongoing stress exposure may disrupt brain circuits involved in emotion regulation, as well as broader systems tied to sleep, cardiovascular function, and inflammation. This cumulative burden—sometimes referred to as “allostatic overload”—may increase vulnerability to post-traumatic stress syndromes and related conditions. “Healthcare workers are repeatedly exposed to high-stakes, unpredictable stressors in environments that often disrupt sleep and recovery,” said Dr. Adrienne Taren, lead author of the study and a researcher at LIBR. “Our work brings together evidence suggesting that these experiences can have measurable effects on the brain and body over time. By understanding these patterns, we have an opportunity to move toward earlier identification and more targeted support for those at risk.” The study also highlights emerging approaches to identifying early signs of risk through multimodal biomarkers, including brain imaging, heart rate variability, sleep patterns, and stress-related biological markers. These tools may help clinicians detect early dysregulation and intervene before symptoms escalate. As healthcare systems nationwide continue to face workforce shortages and rising burnout, the findings underscore the need for new frameworks that recognize the biological impact of chronic occupational stress—and support more proactive, precision-based approaches to care. “This is ultimately about supporting the people who care for others,” Taren added. “By better understanding the biological impact of their work, we can begin to design interventions that are both preventative and responsive to their unique experiences.” The research was conducted in collaboration with LIBR scientists and contributes to a growing global effort to better understand and address the mental health challenges facing healthcare workers and first responders. Read the full study: https://www.tandfonline.com/doi/full/10.1080/20008066.2026.2636453 Dr. Thomas E. Nichols - May 5, 2026
"New Approaches to Modeling Longitudinal Neuroimaging Data" William K. Warren, Jr. Frontiers in Neuroscience Lecture 12:00 pm - 1:00 pm Program in the LPCH auditorium Thomas Nichols is the Professor of Neuroimaging Statistics at the University of Oxford Big Data Institute. He is a statistician with a solitary focus on modelling and inference methods for brain imaging research. He has both industrial and academic experience and a diverse training including computer science, cognitive neuroscience and statistics. He was the Director Modelling and Genetics at GlaxoSmithKline's Clinical Imaging Centre, London, and has been at Oxford since 2017. The focus of his work is developing modelling and inference methods for brain image data, specifically Magnetic Resonance Imaging (MRI) and functional MRI. His current work includes methodology for population scale neuroimaging data, longitudinal studies and neuroimaging genetics. Learning objectives:
Saint Francis Health System designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. For Psychologists: The Oklahoma State Board of Examiners of Psychologists recognizes AMA PRA Category 1 credit(s)™. Saint Francis Health System is accredited by the OSMA. For Social Workers: Saint Francis Health System is an approved CE Provider for the Oklahoma State Board of Licensed Social Workers. This event if approved for 1 hours, Category 1 Clinical. (CEP Number - 20260007) For CADCs and LADCs Saint Francis Health System is accredited as a provider of continuing education programs for CADCs and LADCs through the Oklahoma Board of Licensed Alcohol and Drug Counselors. (1 hour) (Provider Number - 20260008) The LPC/LMFT Saint Francis Health System is a Board approved CE Provider for the State Board of Behavioral Health Licensure (BBHL). This course is approved for 1 hour of CE. For questions, email: Ally Deatherage at [email protected] |
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