THE BODURKA LABORATORY
Jerzy Bodurka, Ph.D.Chief Technology Officer
Director, MRI-EEG Facility Laureate Institute for Brain Research Associate Professor Stephenson School of Biomedical Engineering, The University of Oklahoma Curriculum Vitae Email: jbodurka@laureateinstitute.org | Phone: 918-502-5101
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Research Program Highlights
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Main Question
Can we use brain imaging and/or EEG to directly modulate brain areas that are important for treating anxiety or depression? Approach We use real-time fMRI feedback together with a focus on positive emotion tasks in patients with depression or PTSD to modulate the activation of the amygdala to improve symptoms. |
Current Findings
Depressed patients can learn to enhance amygdala activation to positive emotions, which is associated with a reduction in depressive symptoms. Future Directions We will determine whether this approach can also work with EEG, how long the symptom improvement will last, and whether other types of patients could benefit from real-time fMRI feedback. |
Scientific Background
Dr. Bodurka has broad expertise in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) physics. He received his doctorate degree in physics from the University of Nicolaus Copernicus in Torun, Poland and completed part of his postdoctoral training in NMR at the Department of Chemistry at Free University of Berlin, Germany.
As a postdoctoral fellow at Medical College of Wisconsin, he received firm training in MRI technology and functional MRI (fMRI). As a Staff Scientist at the functional MRI Facility of the National Institute for Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), he was responsible for providing a state-of-the-art imaging environment for conducting advanced MRI and fMRI research.
In 2007, for his development of a Scalable Multi-Channel MRI Data Acquisition System, he received NIH’s Director Award for Advancements in MRI Parallel Imaging Technology. The advancements in MRI receiver and multi-element coils technologies allowed for major improvements in MRI signal-to-noise ratio and pushed spatial and temporal limits for both functional and anatomical imaging. He has also developed an advanced real-time software set-up allowing for conducting real-time fMRI with neurofeedback.
In 2009, Dr. Bodurka joined the newly established Laureate Institute for Brain Research (LIBR) to create a state-of-the-art MRI/fMRI/EEG neuroimaging facility and to a establish multimodal brain neuroimaging program with the overall purpose of advancing clinical research focused on mental disorders, with a broad research goal of advancing our understanding and characterization of brain abnormalities due to mental illness.
As a postdoctoral fellow at Medical College of Wisconsin, he received firm training in MRI technology and functional MRI (fMRI). As a Staff Scientist at the functional MRI Facility of the National Institute for Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), he was responsible for providing a state-of-the-art imaging environment for conducting advanced MRI and fMRI research.
In 2007, for his development of a Scalable Multi-Channel MRI Data Acquisition System, he received NIH’s Director Award for Advancements in MRI Parallel Imaging Technology. The advancements in MRI receiver and multi-element coils technologies allowed for major improvements in MRI signal-to-noise ratio and pushed spatial and temporal limits for both functional and anatomical imaging. He has also developed an advanced real-time software set-up allowing for conducting real-time fMRI with neurofeedback.
In 2009, Dr. Bodurka joined the newly established Laureate Institute for Brain Research (LIBR) to create a state-of-the-art MRI/fMRI/EEG neuroimaging facility and to a establish multimodal brain neuroimaging program with the overall purpose of advancing clinical research focused on mental disorders, with a broad research goal of advancing our understanding and characterization of brain abnormalities due to mental illness.
Lab Members
Masaya Misaki
Staff Scientist Volunteer Faculty Member, Health Sciences Center, University of Oklahoma |
Vadim Zotev
Staff Scientist Volunteer Faculty Member, Department of Electrical and Computer Engineering, University of Oklahoma |
Obada Al Zoubi
Ph.D. Graduate Student, OU |
Beni Mulyana
M.S. Graduate Student, OU |
Jared Smith
Research Assistant |
Aki Tsuchiyagaito
Post-Doctoral Associate |
Selected Publications
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Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder. Misaki M, Phillips R, Zotev V, Wong CK, Wurfel BE, Krueger F, Feldner M, Bodurka J. Neuroimage: Clinical 17:285-296 (2018).
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Altered populations of natural killer cells, cytotoxic T lymphocytes, and regulatory T cells in major depressive disorder: Association with sleep disturbance. Suzuki H, Savitz J, Teague K, Gandhapudi SK, Tan C, Misaki M, McKinney BA, Irwin MR, Drevets WC, Bodurka J. Brain Behav Immun 66:193-200 (2017).
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Randomized clinical trial of real-time fMRI amygdala neurofeedback for major depressive disorder: effects on symptoms and autobiographical memory recall. Young KD, Siegle GJ., Zotev V., Phillips R., Misaki M., Yuan H., Drevets WC., Bodurka J. American Journal of Psychiatry 174(8):748-755. (2017).
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Correlation between amygdala BOLD activity and frontal EEG asymmetry during real-time fMRI neurofeedback training in patients with depression. Zotev V, Yuan H, Misaki M, Phillips R, Young KD, Feldner MT, Bodurka J. Neuroimage Clin. 2016 Feb 12;11:224-38 (2016).
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Individual variations in nucleus accumbens associated with major depressive disorder symptoms. Misaki M, Suzuki H, Savitz J, Drevets WC, Bodurka J. Scientific Reports 6:21227 (2016).
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Automatic EEG-assisted retrospective motion correction for fMRI (aE-REMCOR). Wong CK, Zotev V, Misaki M, Phillips R, Luo Q, Bodurka J. Neuroimage 129:133-147 (2016).
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Research Collaborators
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Kent Teague, Ph.D.
University of Oklahoma- Tulsa Hazem Refai, Ph.D.
University of Oklahoma- Tulsa Samuel Chang, Ph.D.
University of Oklahoma- Tulsa |
Peter Bandettini, Ph.D.
NIH/NIMH, Bethesda, MD Matthew Feldner, Ph.D.
University of Arkansas Frank Krueger, Ph.D.
George Mason University |
Wenming Luh, Ph.D.
Cornell University Michael Roy, M.D.
Uniformed Services University |
Industry Collaborators
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Patrick Britz, Ph.D.
Brain Products GmBH, Germany |
Patrick Ladden, Ph.D.
Nova Medical Inc., Wilmington, MA, USA |
Scott Hinks, Ph.D.
GE Healthcare, Waukesha, WI, USA |
