Podcast: Reward Processing Predicts GAD Treatment Outcomes - A Clinical Trial

This research article explores whether brain activity related to reward and loss before treatment can predict how well adults with generalized anxiety disorder (GAD) improve with either behavioral activation (BA) or exposure therapy (EXP). The study used fMRI to measure neural responses during a monetary incentive task and then randomized participants to ten sessions of BA or EXP. Findings suggest that specific pre-treatment brain activity patterns, particularly in regions like the left caudate and fronto-parietal regions of the cortex, were associated with different outcomes depending on the type of therapy received, highlighting the potential for neural predictors to inform GAD treatment approaches.

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HANNAH BERG,
​Associate Investigator