Podcast: P300 Amplitude Predicts Therapy Completion in Major Depression

This research paper from the Journal of Affective Disorders investigates the relationship between brain activity, measured by P300 amplitude during a reward-based task, and treatment outcomes for individuals with major depressive disorder (MDD). The study found that MDD patients showed smaller P300 amplitudes compared to healthy individuals, indicating reduced neural resource allocation to task stimuli. Furthermore, within the MDD group, individuals with larger P300 amplitudes at the start of treatment were more likely to complete therapy. These findings suggest that P300 amplitude could potentially serve as a predictive marker for treatment adherence in behavioral therapy for depression. 

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Read the full study here

ROBIN AUPPERLE,
​Principal Investigator