Podcast: Ibuprofen's Modulation of Astrocyte-Enriched Extracellular Vesicles and Reward Processing

Our study team explored how ibuprofen, a common anti-inflammatory medication, influences brain function related to reward processing. Researchers focused on astrocyte-enriched extracellular vesicles (AEEVs), tiny particles that facilitate communication between brain cells. They discovered that ibuprofen increases the levels of miR-23b-3p, a specific microRNA within AEEVs. Higher levels of this microRNA were associated with reduced inflammation and enhanced activity in the brain's reward centers during anticipation of rewards. These findings suggest that ibuprofen may have potential benefits for brain health by modulating inflammation and influencing reward-related brain activity.​

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Read the full article on PubMed

aeev_ibuprofen.pdf
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LEANDRA FIGUEROA-HALL,
Principal Investigator