The American Journal of Psychiatry has accepted a paper by Dr. Kym Young and colleagues titled "Amygdala activity during autobiographical memory recall in depressed and vulnerable individuals: Association with symptom severity and autobiographical overgenerality".
The results of this work suggest left amygdala hyperactivity during negative autobiographical recall is a trait-like marker of depression, as both vulnerable groups (individuals remitted from depression, and otherwise healthy individuals at high familial risk of developing depression) showed activity similar to the depressed group, while amygdala hypoactivity during positive autobiographical recall is a state marker of depression manifesting in active disease. Treatments targeting amygdala hypoactivity and blunted salience during positive autobiographical recall conceivably may exert antidepressant effects.
Congratulations to LIBR's Dr. Kym Young and Dr. Jerzy Bodurka on this impressive accomplishment!
The results of this work suggest left amygdala hyperactivity during negative autobiographical recall is a trait-like marker of depression, as both vulnerable groups (individuals remitted from depression, and otherwise healthy individuals at high familial risk of developing depression) showed activity similar to the depressed group, while amygdala hypoactivity during positive autobiographical recall is a state marker of depression manifesting in active disease. Treatments targeting amygdala hypoactivity and blunted salience during positive autobiographical recall conceivably may exert antidepressant effects.
Congratulations to LIBR's Dr. Kym Young and Dr. Jerzy Bodurka on this impressive accomplishment!
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